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Phosphoinositide second messengers in olfaction

R C Bruch1

  • 1Department of Zoology and Physiology, Louisiana State University, Baton Rouge 70803, USA.

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
|March 1, 1996
PubMed
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This review explores how odorants trigger olfactory signaling pathways. It highlights the roles of G-protein-coupled receptors and second messengers like IP3 and DAG in smell perception and signal termination.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Olfactory receptors, part of the G-protein-coupled receptor superfamily, detect odorants.
  • Odorant binding can activate odorant-sensitive phospholipase C (PLC).

Purpose of the Study:

  • To review recent evidence on phosphoinositide-derived second messengers in olfactory signaling.
  • To discuss the role of calcium as a third messenger in olfactory pathways.

Main Methods:

  • Literature review of recent scientific evidence.
  • Summary of molecular mechanisms in olfactory signal transduction.

Main Results:

  • Odorant binding generates inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).

Related Experiment Videos

  • IP3 mediates membrane depolarization via cation channels, while DAG activates protein kinase C (PKC).
  • PKC and G-protein-coupled receptor kinases regulate signal termination through receptor phosphorylation.

    • Conclusions:

    • Phosphoinositide second messengers are crucial for olfactory signaling.
    • Calcium acts as a third messenger, integrating phosphoinositide and cyclic AMP pathways.