Use of intra-aortic nitroglycerin in the cardiac catheterization laboratory

The purpose of this study was to determine whether nitroglycerin (NTG) injected into the ascending aorta or left ventricle would safely and effectively lower blood pressure in hypertensive patients undergoing cardiac catheterization. Fifty bolus injections of 297 +/- 67 micrograms (mean +/- SD) NTG were given to patients with a systolic blood pressure (SBP) of > or = 140 mm Hg (mean SBP 188 +/- 20.1 mm Hg). An average drop in systolic blood pressure of 36 +/- 16 mmHg (P < 0.001), diastolic blood pressure of 19 +/- 7 mm Hg (P < 0.001), and left ventricular end-diastolic pressure of 4.7 +/- 4 mm Hg (P = 0.001) was well tolerated in each patient. The mean time to response was 11 +/- 3 sec. Intra-aortic injection of NTG is a safe and effective means to treat hypertensive patients in the cardiac catheterization laboratory.