Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurosteroids: biosynthesis and function

P Robel1, E E Baulieu

  • 1INSERM U33, Le Kremlin-Bicêtre, France.

Critical Reviews in Neurobiology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stimulation of transcription in vitro from a liver-specific promoter by human glucocorticoid receptor (hGRalpha).

The Biochemical journal·1997
Same author

Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex.

Steroids·1997
Same author

Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons.

The Biochemical journal·1997
Same author

RU486 (mifepristone): mechanisms of action and clinical uses.

Annual review of medicine·1997
Same author

FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.

The Journal of biological chemistry·1996
Same author

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study.

Proceedings of the National Academy of Sciences of the United States of America·1996
Same journal

Dopaminergic modulation of the neuron activity in the cerebral cortex of the wakeful animal.

Critical reviews in neurobiology·2010
Same journal

A new conceptual understanding of brain function: basic mechanisms of brain-initiated normal and pathological behaviors.

Critical reviews in neurobiology·2009
Same journal

Psychiatric implications of hepatitis-C infection.

Critical reviews in neurobiology·2009
Same journal

Methylphenidate treated at the test cage--dose-dependent sensitization or tolerance depend on the behavioral assay used.

Critical reviews in neurobiology·2009
Same journal

Cerebellar-dependent learning as a neurobehavioral index of the cannabinoid system.

Critical reviews in neurobiology·2009
Same journal

The role of intermediate filament proteins in the development of neurological disease.

Critical reviews in neurobiology·2009
See all related articles

Neurosteroids, synthesized within the nervous system, modulate brain functions independently of glands. Glial cells are key in their production, impacting gene expression and neurotransmitter receptors.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cell Biology

Background:

  • Neurosteroids are synthesized in the nervous system from cholesterol or precursors.
  • Their levels are partly independent of peripheral steroidogenic glands.
  • Glial cells are central to neurosteroid synthesis and metabolism.

Purpose of the Study:

  • To define neurosteroids and their synthesis within the nervous system.
  • To elucidate the role of glial cells in neurosteroidogenesis.
  • To explore the functions of neurosteroids in neural regulation.

Main Methods:

  • Literature review on neurosteroid synthesis and function.
  • Analysis of glial cell involvement in neurosteroid pathways.
  • Examination of neurosteroid actions on gene expression and receptors.

Related Experiment Videos

Main Results:

  • Neurosteroids are synthesized de novo or from precursors within the brain.
  • Glial cells significantly contribute to neurosteroid formation and breakdown.
  • Neurosteroids act via autocrine and paracrine mechanisms on target genes and membrane receptors.

Conclusions:

  • Neurosteroids are endogenous brain compounds with critical neuromodulatory roles.
  • Further research is needed to fully understand their involvement in estrus cycle, pregnancy, stress, memory, and aging.