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Updated: Jul 23, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Acetaminophen toxicity is substantially reduced by beta-carotene in mice
Abstract:
Acetaminophen is toxic in overdose and even at routine therapeutic doses in glutathione-deficient populations such as alcoholics and AIDS patients. We were intrigued by the fact that beta-carotene is stored in the liver, the major organ of detoxification, and we speculated that dietary supplementation of beta-carotene would enhance the liver's ability to withstand toxic challenge from acetaminophen. We present a series of experiments which demonstrate that beta-carotene can prevent death or ameliorate toxicity from acetaminophen in mice.
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