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The 5,6-double bond of pyrimidine nucleosides, a fragile site in nucleic acids
1Faculty of Pharmaceutical Sciences, Okayama University.
Journal of Biochemistry
|March 1, 1996
Abstract:
Our studies have revealed reagents that can attack the 5,6-double bond of pyrimidine nucleosides; potassium permanganate and bisulfite. This review is a personal account of these studies, with a discussion on the vulnerable nature of this particular double bond to external nucleophiles and oxidizing agents. The finding that N(4)aminocytidine, produced on treatment of cytidine with bisulfite and hydrazine, is a strong mutagen is also described.