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Sertraline treatment for premature ejaculation

J Mendels1, A Camera, C Sikes

  • 1Philadelphia Medical Institute, Philadelphia, Pennsylvania, USA.

Journal of Clinical Psychopharmacology
|October 1, 1995
PubMed
Summary
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Sertraline significantly improved time to ejaculation and intercourse success in men with premature ejaculation. This medication was well-tolerated and may be a useful treatment option.

Area of Science:

  • Urology
  • Psychiatry
  • Pharmacology

Background:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • Effective and safe treatment options for PE are needed.

Purpose of the Study:

  • To evaluate the efficacy and safety of sertraline for treating premature ejaculation.
  • To assess sertraline's impact on ejaculation latency and sexual intercourse success.

Main Methods:

  • A randomized, placebo-controlled trial involving 52 heterosexual males with PE.
  • Sertraline dosage was titrated from 50 to 200 mg daily over 8 weeks.
  • Efficacy assessed by ejaculation time, intercourse attempts, and clinical improvement.

Main Results:

  • Sertraline significantly increased time to ejaculation compared to placebo.

Related Experiment Videos

  • Patients receiving sertraline reported a higher number of successful intercourse attempts.
  • Overall clinical judgment showed significant improvement with sertraline treatment.

    • Conclusions:

    • Sertraline therapy effectively prolongs ejaculation time in men with premature ejaculation.
    • Sertraline is a potentially beneficial treatment for selected patients experiencing PE.
    • The medication was generally well-tolerated by the study participants.