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Adenovirus mixture isolated from the brain of an AIDS patient with encephalitis
D Schnurr1, A Bollen, L Crawford-Miksza
1Viral and Rickettsial Disease Laboratory, California State Department of Health Services, Berkeley 94704, USA.
Abstract:
A mixture of adenoviruses 31 and 49 was isolated from the brain of an AIDS patient with encephalitis. Adenovirus hexon protein was detected in neurons by indirect immunofluorescence. By restriction endonuclease analysis both adenovirus 31 and 49 were shown to be new genotypes. This is the first report of the isolation of a mixture of adenoviruses from adenovirus encephalitis and the first association of adenovirus 49, a new candidate serotype, with encephalitis.
Insights
A mixture of adenoviruses 31 and 49 was isolated from the brain of an AIDS patient with encephalitis. This study marks the first isolation of mixed adenoviruses causing encephalitis and links adenovirus 49 to the condition.
Area of Science:
- Neurovirology
- Infectious Diseases
- Molecular Biology
Background:
- Encephalitis is a serious neurological condition.
- Adenoviruses are known to cause various infections, but their role in encephalitis is less understood.
- Acquired immunodeficiency syndrome (AIDS) can predispose individuals to opportunistic infections.