HLA frequencies in Pakistani population groups

HLA Antigen A, B and DR frequencies were determined in 912 subjects who were prospective donors and recipients for renal transplantation. Of the 912, 305 were Sindhi, 248 Punjabi, 315 Urdu and 44 Pushto speaking. HLA A1, A2, A11 and A19 were common in all these groups. A3 was more frequent in Pushto, A9 (24) in Punjabi, A10 (26) in Sindhi and A28 in Urdu-speaking group. HLA B5 (51) and B40 (60) were common in all, while B8 in Sindhi and Punjabi, B35 in Sindhi, Urdu and Pushto and B27 in Punjabi and Urdu speaking individuals. HLA-DR3 and DR2 (15) were common in all groups. DR6 (13) in Sindhi, Urdu and Pushto and DR6 (14) in Punjabi, DR5 (11) in Urdu, Punjabi and Pushto speaking subjects. Overall, Pakistani frequencies showed linkage to Caucasians and Orientals. This paper describes differences in frequencies in various population groups within Pakistan which may have relevance in factors where HLA system plays a crucial role.