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Updated: Jul 27, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Autoantibodies in bronchial asthma]
K Fujimori1, E Suzuki, M Arakawa
1Department of Internal Medicine, Niigata Prefectural Shibata Hospital.
Arerugi = [Allergy]
|July 1, 1996
Summary
Non-atopic asthma patients show a higher prevalence of antinuclear antibodies (ANA) compared to atopic asthma patients. This suggests a potential autoimmune link in non-atopic asthma, possibly due to infections and inflammation.
Area of Science:
- Immunology
- Pulmonology
- Autoimmunity
Context:
- Asthma is a heterogeneous respiratory condition with distinct atopic and non-atopic phenotypes.
- Autoantibodies are implicated in various autoimmune and inflammatory diseases.
- Understanding autoantibody prevalence can differentiate asthma subtypes and inform pathogenesis.
Purpose:
- To investigate the difference in autoantibody prevalence between atopic and non-atopic asthma.
- To compare antinuclear antibody (ANA) incidence across asthma subtypes, lung cancer, and control groups.
Summary:
- The study evaluated antinuclear antibodies (ANA) in 20 atopic asthma, 15 non-atopic asthma, 20 lung cancer patients, and 103 controls using indirect immunofluorescence.
- Positive ANA was detected in 4/20 atopic asthma, 8/15 non-atopic asthma, 6/20 lung cancer, and 12/103 controls.
- Significantly higher ANA incidence was observed in non-atopic asthma compared to atopic asthma, irrespective of age or sex.
Impact:
- Findings suggest a higher propensity for autoantibody development in non-atopic asthma.
- Hypothesizes that viral infections and chronic airway inflammation in non-atopic asthma may impair lymphocyte surveillance, promoting autoimmunity.
- Highlights potential differences in the immunological underpinnings of atopic versus non-atopic asthma.
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