Related Experiment Video
Updated: Jul 27, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Autoantibodies in bronchial asthma]
K Fujimori1, E Suzuki, M Arakawa
1Department of Internal Medicine, Niigata Prefectural Shibata Hospital.
Abstract:
We studied the difference in the prevalence of autoantibodies between the sera of atopic asthma and non-atopic asthma. The presence of antinuclear antibodies (ANA) was evaluated in the sera of 20 patients with atopic asthma, 15 with non-atopic asthma, 20 with lung cancer, and 103 control subjects (40 with other pulmonary diseases and 63 with other medical diseases), by using an indirect immunofluorescent assay with HEp-2 cells as a substrate. The incidence of positive ANA was in the sera of 4/20 patients with atopic asthma, 8/15 with non-atopic asthma, 6/20 with lung cancer and 12/103 with control subjects, respectively. The incidence of positive ANA was found to be significantly higher in non-atopic asthma than in atopic asthma regardless of age or sex. One hypothesis is as follows. In non-atopic asthma, viral airway infection, as well as chronic eosinophilic inflammation of the airways, may cause some trouble in the impaired lymphocyte surveillance and may be especially liable to develop autoantibodies under those circumstances.
Related Concept Videos
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Allergic Reactions
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

