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[Evaluation of the stability of lipiodol-CDDP: suspension (LCS) by the pumping method]
K Yamamoto1, T Shimizu, I Narabayashi
1Department of Radiology, Osaka Medical College.
Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica
|August 1, 1996
Abstract:
We purified cisplatin (CDDP) powder from CDDP solution and prepared a Lipiodol-CDDP-suspension (LCS) using the oily contrast medium Lipiodol in order to investigate its stability. Non-ionic contrast materials have surface activity. Iopamidol was chosen as a coupling agent. The compounding ratios of Lipiodol/Iopamidol 300/CDDP for stable suspension were 1 ml/1 ml/10 mg and 1 ml/1 ml/20 mg. These were also obtained easily by using the pumping method.