Intravenous ursodeoxycholic acid reduces cholestasis in parenterally fed newborn piglets
View abstract on PubMed
Summary
This summary is machine-generated.Intravenous ursodeoxycholic acid (UDCA) improved bile flow and reduced bilirubin in piglets with total parenteral nutrition (TPN)-induced cholestasis. UDCA did not normalize bile composition but enhanced hepatocyte function.
Area Of Science
- Neonatal physiology
- Gastroenterology
- Hepatology
Background
- Cholestasis is a common complication of total parenteral nutrition (TPN) in preterm infants.
- Ursodeoxycholic acid (UDCA) is a potential therapeutic agent for cholestatic conditions.
Purpose Of The Study
- To investigate whether intravenous UDCA can prevent TPN-induced cholestasis in piglets.
- To assess UDCA's effects on bile flow, bile composition, and hepatocyte membrane function.
Main Methods
- Piglet model with three groups: sow's milk, TPN, and TPN with intravenous UDCA.
- Measurement of basal and stimulated bile flow after 3 weeks.
- Analysis of bile and hepatocyte membrane composition, including lipids and Na+,K(+)-ATPase activity.
Main Results
- TPN significantly reduced bile acid secretion and bile flow compared to controls.
- Intravenous UDCA treatment improved bile flow and hepatocyte Na+,K(+)-ATPase activity in TPN-fed piglets.
- UDCA did not normalize TPN-induced alterations in bile composition, but sinusoidal membrane fluidity was preserved.
Conclusions
- Intravenous UDCA effectively improves bile flow and reduces bilirubin levels in TPN-induced cholestasis in piglets.
- UDCA demonstrates a protective effect on hepatocyte function, although bile composition normalization was not observed.