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Synthesis of heterocycles containing two cytosine or two guanine base-pairing sites. Novel tectons for self-assembly
P M Petersen1, W Wu, E E Fenlon
1Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana 61801, USA.
Bioorganic & Medicinal Chemistry
|July 1, 1996
Abstract:
The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.