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Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele
E Jönsson1, L Lannfelt, B Engvall
1Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
European Archives of Psychiatry and Clinical Neuroscience
|January 1, 1996
Abstract:
The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the epsilon 4 allele may play a role also in schizophrenia, another mental disorder, patients (n = 87) and control subjects (n = 57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.