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Plateletpheresis using the haemonetics model 30 cell separator

J Nusbacher, M L Scher, J L MacPherson

    Vox Sanguinis
    |July 1, 1977
    PubMed
    Summary
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    Plateletpheresis using the Haemonetics Model 30 effectively collects platelets. Transfused platelets yield comparable results to standard methods, despite some cell loss during processing.

    Area of Science:

    • Transfusion Medicine
    • Hematology

    Background:

    • Plateletpheresis is a method for collecting platelets from donors.
    • The Haemonetics Model 30 is a commonly used apheresis device.

    Purpose of the Study:

    • To evaluate the efficacy and characteristics of platelet collection using the Haemonetics Model 30.
    • To assess the impact of processing on collected platelets and donor platelet counts.

    Main Methods:

    • Plateletpheresis was performed using the Haemonetics Model 30.
    • Collected platelet products were analyzed for cellular content.
    • Centrifugation was used to remove unwanted cells, with subsequent platelet loss noted.
    • Donor platelet counts were monitored before and after the procedure.

    Main Results:

    Related Experiment Videos

    • A mean collection of 5.5 X 10(11) platelets was achieved.
    • Collected products contained erythrocytes and mononuclear cells, removable by centrifugation with a 23% platelet loss.
    • Donor platelet count decreased by a mean of 78,000/mm3, suggesting donor platelet mobilization.
    • Transfused platelets resulted in comparable increments to standard batch-processed platelets.

    Conclusions:

    • The Haemonetics Model 30 is effective for platelet collection.
    • Processing steps can lead to platelet loss, but collected platelets are clinically effective.
    • Donor platelet mobilization occurs during apheresis.