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Updated: Aug 12, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 28, 2010
Resistance to Leishmania major induced by tolerance to a single antigen
V Julia1, M Rassoulzadegan, N Glaichenhaus
1CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.
Abstract:
In mice, susceptibility to Leishmania major is associated with the early expansion of T helper 2 cells (TH2) cells, but nothing is known of the specificity of these cells. A previously identified antigen, Leishmania homolog of receptors for activated C kinase (LACK), was found to be the focus of this initial response. Mice made tolerant to LACK by the transgenic expression of the antigen in the thymus exhibited both a diminished TH2 response and a healing phenotype. Thus, T cells that are activated early and are reactive to a single antigen play a pivotal role in directing the immune response to the entire parasite.
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