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Relaxation response to the rat stomach fundus to methylene blue
K Kamata1, M Kohzuki, Y Kasuya
1Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan.
Research Communications in Molecular Pathology and Pharmacology
|February 1, 1996
Abstract:
When methylene blue (10(-4) M) was applied to the rat stomach fundus precontracted with 10(-6) M serotonin in the presence of 10(-6)M atropine and 10(-6) M guanethidine, slowly developing relaxation was induced. Methylene blue (10(-4) M) increased cyclic AMP but not cyclic GMP levels in the stomach fundus. These results suggest that methylene blue may relax the rat stomach fundus through cyclic AMP formation.