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Expression of autocrine motility factor receptor in cutaneous malignant melanoma
Y Nagai1, O Ishikawa, Y Miyachi
1Department of Dermatology, Gunma University School of Medicine, Maebashi, Japan.
Background:
The autocrine motility factor receptor (AMFR), a specific receptor for AME, is considered to be related to the metastatic potential of tumor cells.
Objective:
We investigated whether AMFR is expressed on cutaneous malignant melanoma cells and has any relationship to clinical stage and metastatic ability.
Methods:
We performed an immunohistochemical study on 20 cases of cutaneous malignant melanoma using anti-AMFR antibody. AMFR was expressed in 9 cases (45%), and its expression had a tendency to correlate with the clinical stage and the presence of lymph node metastasis.
Conclusions:
The expression of AMFR may have a possible association with the metastatic potential of malignant melanoma.