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Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

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Published on: June 19, 2015

Pseudomonas bacteremia precipitated by ticlopidine-induced neutropenia

S M Geletko1, K M Melbourne, D J Mikolich

  • 1College of Pharmacy, University of Rhode Island, Providence, USA.

The Annals of Pharmacotherapy
|March 1, 1996
PubMed
Abstract

Insights

Ticlopidine can cause sudden neutropenia, a dangerous drop in white blood cells. This case highlights the risk of severe Pseudomonas bacteremia in patients with ticlopidine-induced neutropenia.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • Ticlopidine is an antiplatelet medication.
  • Neutropenia is a condition characterized by a low count of neutrophils, a type of white blood cell.

Observation:

  • An 83-year-old male developed febrile neutropenia (white blood cell count 1.1 x 10(9)/L, absolute neutrophil count 0) 5 days after starting ticlopidine.
  • Blood cultures confirmed Pseudomonas aeruginosa bacteremia.

Findings:

  • Ticlopidine was discontinued, and the patient received ceftazidime, gentamicin, and filgrastim.
  • The patient improved clinically with resolution of neutropenia (ANC 17,040 x 10(6) cells/L) after 6 days of treatment.

Implications:

  • Ticlopidine-induced neutropenia can manifest abruptly and lead to severe infections like bacteremia.
  • Prompt recognition and management, including discontinuation of the offending drug and supportive care, are crucial.

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