Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Koilocytosis; an indication for conservative management

N Dudding1, J Sutton, S Lane

  • 1Department of Histopathology, The General Infirmary at Leeds, UK.

Cytopathology : Official Journal of the British Society for Clinical Cytology
|February 1, 1996
PubMed
Summary

Koilocytosis, a feature in cervical smears, indicates a low risk of cervical intraepithelial neoplasia (CIN), particularly high-grade CINIII. This finding suggests modifying management strategies for women with koilocytic smears.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient specific in vitro follicle development in response to ovarian freezing and culture.

Reproduction & fertility·2026
Same author

Three-dimensional visualisation of human ovarian follicles using a whole-mount immunolabelling and optical tissue clearing method.

Reproduction & fertility·2025
Same author

Influence of routine follow-up radiographs on recommendations for management of antebrachial fractures in dogs.

Australian veterinary journal·2025
Same author

Anthropometric and Physiological Measures in Individuals With At-Risk Mental State (ARMS) Compared With Individuals With Schizophrenia: Findings From a Lower Middle-Income Country.

Early intervention in psychiatry·2025
Same author

Four-dimensional ultrasound guided embryo transfers improve live birth rates when compared to the clinical touch technique: a randomised controlled trial.

Scientific reports·2023
Same author

Demographic and clinical correlates of suicidal ideation in individuals with at-risk mental state (ARMS): A study from Pakistan.

Early intervention in psychiatry·2023

Area of Science:

  • Gynecologic pathology
  • Cervical cancer screening
  • Cytopathology

Background:

  • Management of mild dyskaryosis in cervical smears remains debated.
  • Identifying morphological features to predict cervical intraepithelial neoplasia (CIN) grade is crucial for improved patient management.

Purpose of the Study:

  • To evaluate the association between koilocytosis and the risk of underlying or progressive cervical intraepithelial neoplasia (CIN).
  • To determine if koilocytosis is a reliable indicator of low or high-grade CIN.

Main Methods:

  • Retrospective review of 244 cervical smears initially reported with evidence of warty virus infection.
  • Detailed analysis of 173 smears showing clear koilocytosis.
  • Correlation of cytological findings with subsequent histological diagnoses of CIN over a minimum 21-month follow-up period.

Related Experiment Videos

Main Results:

  • Only 16.2% of cases with koilocytosis had underlying CIN or progressed to CIN.
  • A very low incidence of high-grade CINIII (1.2%) was observed in women with koilocytic smears.
  • Koilocytosis was associated with a significantly low risk of developing CIN, especially CINIII.

Conclusions:

  • Koilocytosis in cervical smears is linked to a low risk of cervical intraepithelial neoplasia (CIN).
  • The presence of koilocytosis indicates an especially low risk for high-grade CINIII.
  • Management protocols for women with koilocytic cervical smears may require adjustment based on these findings.