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Related Experiment Videos

Adhesion molecules in autoimmune disease

R W McMurray1

  • 1Department of Internal Medicine, University of Mississippi Medical Center, Jackson 39214-4505, USA.

Seminars in Arthritis and Rheumatism
|February 1, 1996
PubMed
Summary
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Adhesion molecules are crucial for leukocyte movement in autoimmune diseases. Targeting these molecules shows promise in preventing or reducing disease severity in experimental models and early human trials.

Area of Science:

  • Immunology
  • Cell Biology
  • Rheumatology

Background:

  • Leukocyte adhesion to cells and extracellular matrix is vital for immune responses.
  • Adhesion molecule expression and interactions are implicated in the initiation and progression of autoimmune diseases.

Purpose of the Study:

  • To review adhesion molecules relevant to autoimmunity.
  • To classify adhesion molecules and discuss their regulation and role in specific autoimmune diseases.

Main Methods:

  • Manual and computerized literature search on adhesion molecules and autoimmune diseases.
  • Review of adhesion molecule classification, regulation, and receptor characterization.
  • Analysis of key adhesion interactions in autoimmune inflammation.

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Main Results:

  • Adhesion molecules are classified into selectin, integrin, and immunoglobulin supergene families.
  • Leukocyte adhesion is regulated by increased expression and avidity changes.
  • Key interactions include selectins, integrins (LFA-1/ICAM-1, VLA-4/VCAM-1), and others.
  • Anti-adhesion molecule therapies show success in animal models and preliminary human trials for rheumatoid arthritis.

Conclusions:

  • Adhesive interactions are integral to autoimmune disease pathogenesis.
  • Further research into leukocyte migration and adherence can identify therapeutic targets.