[Local use of levomycetin in neurosurgery]

A method of local application of the unsoluble medicinal form of chloramphenicol during operations has been developed. Administration of the preparation in a dose up to 2g under an osteal or cutaneous graft induces no side complications and forms a depot of the agent therapeutic concentrations for more than 8 days. There exists a direct relationship between the increasing of staphylococcus resistance to chloramphenicol and the quantity of the agent used in patients.