The Dubin Johnson syndrome and pregnancy

A recent summary of the scanty information about Dubin Johnson Syndrome (DJS) and pregnancy suggests that DJS is accompanied by excessive fetal mortality. This impression could not be corroborated by this study. A fetal mortality of 16% was observed in 75 pregnancies in 18 DJS patients. This value was not significantly different from the 10% mortality observed in 81 pregnancies in 15 matched control subjects. Jaundice was accentuated in 54% of pregnancies in the DJS patients and its time of onset was variable. In 6 instances jaundice was observed only following delivery.