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[Helicobacter pylori--comparison of selected diagnostic methods]
Z Kopański1, A Cienciała, Z Ulatowski
1Kliniczny Oddział Chirurgii Ogólnej 5 Wojskowego Szpitala Klinicznego w Krakowie.
Folia Medica Cracoviensia
|January 1, 1995
Summary
Diagnosing Helicobacter pylori infection in gastritis patients revealed varying detection rates among methods. Combining serologic tests and histological examination offers the highest diagnostic accuracy for H. pylori.
Area of Science:
- Gastroenterology
- Microbiology
- Medical Diagnostics
Background:
- Helicobacter pylori is a significant pathogen associated with chronic gastritis, peptic ulcers (ulcus ventriculi and ulcus doudeni).
- Accurate diagnosis of H. pylori infection is crucial for effective patient management and treatment strategies.
Purpose of the Study:
- To evaluate the diagnostic efficacy of different methods for detecting Helicobacter pylori in patients with chronic gastritis.
- To determine the optimal combination of diagnostic techniques for maximizing the detection rate of H. pylori infection.
Main Methods:
- Simultaneous utilization of direct tissue preparation (gastrobiopsy), histological preparation (Giemza staining), bacterial culture, and serologic tests (ELISA, IFP).
- Analysis of diagnostic results in 108 patients diagnosed with chronic gastritis, including those with gastric and duodenal ulcers.
- Discrimination analysis was employed to assess the combined diagnostic value of different methods.
Main Results:
- Detection rates for H. pylori varied significantly by method: direct preparation (20%), histological preparation (63.8%), culture (68.1%), and serologic tests (81.5%).
- Differences in H. pylori prevalence were observed based on the diagnostic method employed.
- A combination of serologic testing and histological examination demonstrated the highest diagnostic value.
Conclusions:
- Serologic tests provide the highest individual detection rate for H. pylori in this patient cohort.
- Combining serologic tests with histological examination is recommended for optimal diagnosis of Helicobacter pylori infection in patients with chronic gastritis and associated ulcers.