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Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect
J G den Hollander1, J W Mouton, I A Bakker-Woudenberg
1Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, Netherlands.
Antimicrobial Agents and Chemotherapy
|February 1, 1996
Abstract:
To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.