Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mega-trials: is meta-analysis an alternative?

J Lubsen1

  • 1SOCAR Research SA, Givrins, Switzerland.

European Journal of Clinical Pharmacology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Mechanized Pediatric Elbow Joint Powered by a De-Based Artificial Skeletal Muscle.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Survival analysis in total joint replacement: an alternative method of accounting for the presence of competing risk.

The Journal of bone and joint surgery. British volume·2010
Same author

Treatment of angina pectoris: associations with symptom severity.

International journal of cardiology·2005
Same author

Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

Statistics in medicine·2000
Same author

Implications of trial results: the potentially misleading notions of number needed to treat and average duration of life gained.

Lancet (London, England)·2000
Same author

Heart failure treatments: issues of safety versus issues of quality of life.

Drug safety·1999
Same journal

Efficacy and safety of Ensitrelvir in COVID-19 patients: a systematic review and meta-analysis with focus on viral clearance and RNA change.

European journal of clinical pharmacology·2026
Same journal

Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines.

European journal of clinical pharmacology·2026
Same journal

The efficacy of letrozole in the medical management of ectopic pregnancy: a systematic review and meta-analysis.

European journal of clinical pharmacology·2026
Same journal

Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools.

European journal of clinical pharmacology·2026
Same journal

Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment.

European journal of clinical pharmacology·2026
Same journal

Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin.

European journal of clinical pharmacology·2026
See all related articles

Meta-analysis of clinical trials for the ACE inhibitor ramipril in heart failure patients demonstrated a significant 32% reduction in death or hospitalization events. Careful planning of drug development programs is essential for future meta-analyses.

Area of Science:

  • Cardiology
  • Clinical Pharmacology
  • Evidence-Based Medicine

Background:

  • Conducting large-scale placebo-controlled trials with clinical endpoints is challenging when effective treatments are already available.
  • Assessing the efficacy of new drugs like ACE inhibitors requires innovative approaches when traditional trial designs are not feasible.

Purpose of the Study:

  • To evaluate the clinical efficacy of the ACE inhibitor ramipril in patients with heart failure.
  • To determine if meta-analysis of existing placebo-controlled phase III trials can reliably assess clinical endpoints.

Main Methods:

  • A meta-analysis was performed on five exercise capacity trials involving similar heart failure patients treated with ramipril.
  • The analysis utilized the 'intention-to-treat' principle, standard for large-scale clinical trials.

Related Experiment Videos

Main Results:

  • The meta-analysis revealed that ramipril significantly reduced the combined endpoint of death or hospitalization by 32% (P = 0.05).
  • This finding supports the utility of meta-analysis in situations where large-scale individual trials are impractical.

Conclusions:

  • Meta-analysis of available trial data is a viable strategy to assess the clinical effectiveness of drugs like ramipril when traditional trials are not feasible.
  • Drug development programs should be strategically designed to facilitate such meta-analyses for robust efficacy evaluation.