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Oesophageal reflux and asthma

J G Ayres1

  • 1Chest Research Institute, Birmingham Heartlands Hospital, UK.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|December 1, 1995
PubMed
Summary
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Gastro-oesophageal reflux (GOR) and asthma share causal links, often involving vagal reflex pathways rather than direct aspiration. Managing reflux does not always improve asthma, and surgical interventions remain debated.

Area of Science:

  • Gastroenterology
  • Pulmonology
  • Clinical Medicine

Background:

  • Gastro-oesophageal reflux (GOR) and asthma are prevalent conditions with established causal associations.
  • The link between GOR and asthma involves vagal reflex pathways from esophageal receptors triggering airway narrowing and cough.
  • Asthma treatments like smooth muscle relaxants and hyperinflation can exacerbate GOR.

Purpose of the Study:

  • To explore the complex relationship between gastro-oesophageal reflux and asthma.
  • To investigate the mechanisms underlying the association between these two conditions.
  • To evaluate the efficacy of current treatment strategies for GOR in managing asthma symptoms.

Main Methods:

  • Review of existing literature on the interplay between GOR and asthma.

Related Experiment Videos

  • Analysis of documented cases of microaspiration and vagal reflex pathways.
  • Discussion of pharmacological and surgical treatment outcomes.

    • Main Results:

    • Vagal reflex pathways are the predominant mechanism linking GOR to airway narrowing and cough in most asthma patients.
    • Direct microaspiration into the trachea is less common.
    • Pharmacological control of GOR symptoms with H2 blockers or proton pump inhibitors does not consistently improve asthma control.
    • The role of surgery in managing asthma symptoms related to GOR is not definitively established.

    Conclusions:

    • The relationship between GOR and asthma is multifactorial, primarily mediated by vagal reflexes.
    • Current medical treatments for GOR offer limited benefit for asthma control.
    • Further research is needed to clarify the role of surgical interventions for GOR in asthma management.