Related Experiment Videos
Comparison of ceftriaxone versus cefotaxime for childhood upper urinary tract infections
A Bakkaloglu1, U Saatci, O Soylemezoglu
1Pediatric Nephrology Department, Hacettepe University Children's Hospital, Ankara, Turkey.
Insights
Ceftriaxone demonstrated superior efficacy over cefotaxime in treating childhood pyelonephritis, leading to significantly lower recurrence rates. This study highlights ceftriaxone as a favorable option for upper urinary tract infections (UTIs) in children.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology and Therapeutics
- Nephrology
Background:
- Upper urinary tract infections (UTIs) require prompt and effective treatment to prevent sequelae.
- Childhood pyelonephritis is a significant concern requiring optimal antibiotic therapy.
- Cephalosporins are commonly used antibiotics for UTIs.
Purpose of the Study:
- To compare the clinical efficacy of ceftriaxone and cefotaxime in treating childhood pyelonephritis.
- To evaluate the recurrence and reinfection rates associated with each antibiotic.
- To assess the safety and tolerability of ceftriaxone versus cefotaxime.
Main Methods:
- A comparative study involving pediatric patients with pyelonephritis.
- Ten-day course of either ceftriaxone or cefotaxime therapy.
- Assessment of bacterial eradication, cure rates, recurrence, and adverse events.
Main Results:
- Successful bacterial eradication was achieved by day two for both ceftriaxone and cefotaxime.
- Ceftriaxone group showed a significantly better overall cure rate, with fewer recurrences and reinfections (p < 0.05).
- Ceftriaxone exhibited a trend towards superiority in preventing recurrent infections in complicated cases, with no serious adverse effects noted.
Conclusions:
- Ceftriaxone is clinically and bacteriologically effective for both complicated and uncomplicated upper UTIs in children.
- The once-daily dosing of ceftriaxone offers a significant advantage over twice-daily cefotaxime.
- Ceftriaxone is a favorable therapeutic option for childhood pyelonephritis due to its efficacy and convenient dosing schedule.
Abstract:
It is very important to treat patients with upper urinary tract infections (UTIs) promptly and effectively because of the potential sequelae. In the present study we compare the efficacy of the two cephalosporins, ceftriaxone and cefotaxime, in childhood pyelonephritis. The study protocal included 10 days of drug therapy. Both in patients receiving ceftriaxone and cefotaxime, successful eradication was achieved at the second day of therapy. The overall cure rate was significantly better in the ceftriaxone group than the cefotaxime group in terms of recurrence and reinfections (p < 0.05). Furthermore, in the complicated group, ceftriaxone was slightly superior to cefotaxime, approaching significance in terms of preventing recurrent infections. No serious adverse effects were observed in either of the groups. The present study has shown that ceftriaxone exhibits favorable clinical and bacteriologic efficacy in patients with complicated and uncomplicated upper UTI. Once-daily injection of ceftriaxone in children is also an attractive advantage of the drug when compared to twice-daily cefotaxime.