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Sjögren's syndrome: terminology
P Oxholm1, K Asmussen, T Axéll
1Sjögren's Syndrome Research Centres at: Rigshospitalet, National University Hospital, Copenhagen, Denmark.
Clinical and Experimental Rheumatology
|November 1, 1995
Summary
Sjögren's syndrome (SS) lacks consistent terminology and criteria. This study proposes a new classification model for primary SS, defining distinct "exocrine" and "non-exocrine" subgroups for better understanding and clinical evaluation.
Area of Science:
- Rheumatology
- Immunology
- Clinical Medicine
Background:
- Sjögren's syndrome (SS) diagnosis and classification lack consensus despite advances in pathobiology.
- Current terminology for primary and secondary SS requires refinement based on emerging insights.
Purpose of the Study:
- To address the lack of consensus in Sjögren's syndrome terminology and criteria.
- To propose a novel classification model for the immunoinflammatory manifestations of primary SS.
Main Methods:
- Survey of current understanding and discrepancies in Sjögren's syndrome description.
- Definition of new subgroups based on immunoinflammatory manifestations.
Main Results:
- Identified significant discrepancies in the current description of Sjögren's syndrome.
- Proposed a new classification with three "exocrine" and four "non-exocrine" subgroups for primary SS manifestations.
Conclusions:
- The proposed classification model for primary SS manifestations requires validation through clinical studies and interdisciplinary debate.
- Retaining current nomenclature for Sjögren's disease and its primary/secondary subsets is recommended pending further pathobiological discoveries.