Vasculitis and psoriatic arthritis associated with Down's syndrome

Only a few observations of inflammatory arthritis have been associated with Down's syndrome. We report a case of severe erosive, peripheral and axial psoriatic arthritis associated with cutaneous vasculitis in a 24-year old man with trisomy 21. A long standing remission of vasculitis and arthritis was achieved with corticoid and azathioprine treatment. The relationship between chromosomal abnormalities and synovial proliferation is further discussed.