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Aging and matrix microdamage accumulation in human compact bone

M B Schaffler1, K Choi, C Milgrom

  • 1Breech Research Laboratory, Henry Ford Health Sciences Center, Detroit, MI, USA.

Bone
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

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Bone microcracks accumulate with age, particularly in women, increasing fracture risk. This age-related bone damage outpaces natural repair, weakening bones and reducing their resistance to fractures.

Area of Science:

  • Biomaterials Science
  • Orthopedics
  • Gerontology

Background:

  • Bone microcracks, or matrix microdamage, result from cyclic loading.
  • While microdamage is known in rib cortex, its presence in human long bones is understudied.

Purpose of the Study:

  • To investigate the incidence and location of microcracks in human femoral compact bone.
  • To determine the relationship between age and microcrack accumulation in long bones.

Main Methods:

  • Histomorphometric analysis of human femoral compact bone specimens.
  • Least squares regression to analyze microcrack density (Cr.De.) in relation to age.

Main Results:

  • Microdamage in femoral bone significantly increases with age in both sexes.

Related Experiment Videos

  • Microcrack density shows an exponential increase with age in males (r²=0.70) and females (r²=0.79).
  • The rate of microcrack accumulation is significantly higher in females than in males (p<0.001).

    • Conclusions:

    • Bone microdamage accumulates faster than repair mechanisms can cope with aging.
    • Factors like loading history, material property changes, and altered tissue response contribute to microdamage.
    • Accumulated microdamage decreases bone strength, stiffness, and fracture resistance, contributing to skeletal fragility in aging individuals.