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HLA-B27 and HLA-B73 polymorphism and its role on antigenicity, peptide presentation, and disease susceptibility
1Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Spain.
Clinical Rheumatology
|January 1, 1996
Abstract:
Current ideas on the structure, evolution, and disease association of HLA-B27 antigens are presented, with emphasis on the effect of HLA-B27 polymorphism on T-cell recognition and antigen-presenting properties of these molecules. The molecular relationship between HLA-B27 and HLA-B73, and its implications for a putative pathogenetic role of the later antigen are discussed.