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Effect of the antiallergic drug disodium cromoglycate on phosphodiesterase activity
1Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Basque Country, Vitoria-Gasteiz, Spain.
Journal of Enzyme Inhibition
|January 1, 1996
Abstract:
The antiallergic drug disodium cromoglycate and its non-antiallergic analogue dicoumarol, inhibit the enzymatic activity of phosphodiesterase with KI values of 0.8.10(-9) M and 1.6.10(-9) M, respectively. It seems that the dichromone group is responsible for this inhibition, independently of its antiallergic effect.