Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic stem cells in liver regeneration

S S Thorgeirsson1

  • 1Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|September 1, 1996
PubMed
Summary

Liver stem cells activate during regeneration, but only contribute significantly when damaged liver cells cannot proliferate. Growth factors are crucial for stem cell activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.

Oncogene·2015
Same author

NANOG modulates stemness in human colorectal cancer.

Oncogene·2012
Same author

The eyes of transforming growth factor-sZ1 (TGF-sZ1) transgenic mice Morphology and the development of endotoxin-induced uveitis.

Ocular immunology and inflammation·2012
Same author

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.

Oncogene·2012
Same author

The central role of the c-Met pathway in rebuilding the liver.

Gut·2012
Same author

Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response.

Oncogene·2011

Area of Science:

  • Hepatology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • The liver possesses epithelial stem cells with properties similar to those in other tissues.
  • Liver epithelial cell populations, including hepatocytes and bile duct cells, differ in dynamics from classic stem cell systems.

Purpose of the Study:

  • To review recent findings on liver stem cell activation and expansion in vivo.
  • To elucidate the role of liver stem cells in liver regeneration.

Main Methods:

  • Review of recent in vivo studies on liver stem cell activation.
  • Analysis of growth factor requirements for stem cell activation.
  • Investigation of proliferation responses in differentiated liver cells and stem cells following liver mass loss.

Related Experiment Videos

Main Results:

  • Selective and sustained growth factor expression is essential for early stem cell activation.
  • Both quiescent liver stem cells and differentiated hepatocytes/bile duct cells proliferate after liver mass loss.
  • Liver stem cell contribution to regeneration is significant only when differentiated cells are compromised or unable to proliferate.

Conclusions:

  • Liver regeneration involves activation of both stem and differentiated cells.
  • The functional status of differentiated liver cells dictates the extent of stem cell involvement in regeneration.
  • Growth factor signaling plays a critical role in initiating liver stem cell responses.