Akathisia resulting from traumatic brain injury

Restlessness and agitation are commonly reported early sequelae of traumatic brain injury (TBI). Severe restlessness (akathisia) is also observed in psychiatric patients as a result of the use of dopamine receptor blocking agents. A recent case study described akathisia in a patient with bilateral orbitofrontal lesions following TBI. We report a case of unusually marked motor restlessness (akathisia) following TBI in a 17-year-old woman. When admitted for rehabilitation she was alert but agitated, severely restless, and mute. She constantly paced her room and the hospital unit, repeatedly retracing the same route. MRI scan revealed large, well-delineated bifrontal contusions. During baseline evaluation prior to anticipated psychopharmacological intervention her restlessness began to resolve rapidly. She became verbal and oriented within expected limits without medication. This case lends support to the observation that akathisia is related to lesions of the prefrontal cortex.