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Related Experiment Videos

Exercise-induced bronchial hyperresponsiveness and parental ISAAC questionnaire responses

A L Ponsonby1, D Couper, T Dwyer

  • 1Menzies Centre for Population Health Research, University of Tasmania, Hobart, Australia.

The European Respiratory Journal
|July 1, 1996
PubMed
Summary

Parental reports of wheeze and asthma symptoms accurately predict exercise-induced bronchoconstriction in children. This supports using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for assessing childhood asthma.

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Area of Science:

  • Pediatric Respiratory Medicine
  • Epidemiology of Asthma
  • Allergy and Immunology

Background:

  • The predictive accuracy of parental questionnaires for exercise-induced bronchoconstriction (EIB) in childhood asthma remains unclear.
  • Understanding this relationship is crucial for accurate asthma diagnosis and prevalence estimation in large-scale studies.

Purpose of the Study:

  • To evaluate the correlation between parental responses to core International Study of Asthma and Allergies in Childhood (ISAAC) questions and objective measures of exercise-induced bronchial hyperresponsiveness (EIBH) in 7-year-old children.
  • To assess the utility of exercise challenge testing as a diagnostic tool for current asthma and exercise-induced wheeze.

Main Methods:

  • A cross-sectional study involving 191 children aged 7 years from Southern Tasmania.

Related Experiment Videos

  • Data collection included parental questionnaires (ISAAC core questions) and standardized 6-minute free-running exercise challenge tests.
  • Pulmonary function was assessed via forced expiratory volume in one second (FEV1) measurements pre- and post-exercise.

    • Main Results:

    • Children whose parents reported a history of wheeze or asthma, recent wheeze, wheeze-related sleep disturbance, or exercise-induced wheeze showed significantly higher median percentage falls in FEV1 post-exercise (p < 0.0031).
    • Receiver operating characteristic (ROC) curve analysis indicated that EIBH is a strong predictor of current asthma status.
    • Exercise challenge testing (≥12% fall in FEV1) demonstrated sensitivity and specificity of 0.58/0.77 for current asthma and 0.60/0.77 for exercise-induced wheeze.

    Conclusions:

    • Parental responses to ISAAC questionnaire items regarding respiratory symptoms align well with objective measurements of exercise-induced respiratory responses in young children.
    • These findings validate the use of parental ISAAC questionnaire data for interpreting asthma prevalence in population-based studies.
    • Exercise challenge testing serves as a reliable indicator for diagnosing EIB and current asthma in pediatric populations.