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Coagulation inhibitors and fibrinolytic parameters in patients on peritoneal dialysis and haemodialysis

J Alwakeel1, A M Gader, S Hurieb

  • 1Department of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.

International Urology and Nephrology
|January 1, 1996
PubMed

Insights

Continuous ambulatory peritoneal dialysis (CAPD) patients show higher coagulation inhibitors than hemodialysis (HD) patients, suggesting a protective mechanism against thrombosis in both dialysis groups despite differences in inhibitor levels.

Area of Science:

  • Nephrology
  • Hematology
  • Clinical Chemistry

Background:

  • Dialysis patients often experience altered coagulation and fibrinolysis.
  • Understanding these changes is crucial for managing thrombotic risk.

Purpose of the Study:

  • To compare coagulation inhibitors and fibrinolytic parameters in patients undergoing CAPD versus HD.
  • To assess the impact of different dialysis modalities on hemostasis.

Main Methods:

  • Assessed levels of Antithrombin III (ATIII), Proteins C and S, tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI).
  • Compared parameters between 12 CAPD patients, 10 HD patients, and healthy controls.

Main Results:

  • CAPD patients had higher ATIII, Protein C, and Protein S than HD patients.
  • HD patients showed significantly lower ATIII and Protein C compared to controls.
  • Both CAPD and HD patients exhibited higher tPA levels than controls, with no significant difference in PAI levels between patient groups and controls.

Conclusions:

  • Hemodialysis is associated with a significant decrease in circulating coagulation inhibitors.
  • Continuous ambulatory peritoneal dialysis patients maintain elevated levels of these inhibitors.
  • Enhanced fibrinolysis in both groups may represent a compensatory mechanism against thrombotic tendencies.

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