Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histopathologic findings in chronic hepatitis C

H P Fischer1, E Willsch, E Bierhoff

  • 1Institute of Pathology, University of Bonn, Germany.

Journal of Hepatology
|January 1, 1996
PubMed
Summary

Liver biopsies are crucial for diagnosing and staging hepatitis C virus (HCV) infection. Coinfection with HIV and HCV significantly accelerates liver fibrosis and cirrhosis, particularly in hemophiliacs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Report of the German Society for Pathology Dermatopathology Working Group].

Pathologie (Heidelberg, Germany)·2024
Same author

High efficacy of red light photodynamic therapy with 10 % aminolevulinic acid gel irrespective of the extent of keratinocyte atypia in actinic keratosis - exploratory post-hoc analysis of three pivotal phase III trials.

Photodiagnosis and photodynamic therapy·2024
Same author

[Report of the Dermatopathology Working Group of the German Society for Pathology].

Pathologie (Heidelberg, Germany)·2023
Same author

[Report of the meeting of the dermatopathology working group : On Thursday 9 June 2022, 4:30 p.m. to 6:30 p.m., as part of the annual conference of the DGP, in Munster].

Pathologie (Heidelberg, Germany)·2022
Same author

[Rare tumor of the limbus: solitary benign fibrous histiocytoma].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2022
Same author

[Report of the Dermatopathology Working Group meeting during the Virtual Pathology Days of the DGP 2021, Berlin : 8 June 2021 at 7:00 p.m. s.t.]

Der Pathologe·2021

Area of Science:

  • Hepatology
  • Virology
  • Pathology

Background:

  • Liver biopsy is essential for diagnosing hepatitis C virus (HCV) infection, assessing disease severity, and differentiating it from other liver conditions.
  • Chronic HCV infection typically progresses slowly but can accelerate due to inflammatory activity, diminishing the predictive value of traditional classifications.
  • Distinct morphological features, including portal lymphoid aggregates and bile duct damage, help differentiate HCV from other progressive liver diseases.

Purpose of the Study:

  • To evaluate the role of liver biopsies in the comprehensive assessment of chronic hepatitis C.
  • To identify characteristic histopathological features of HCV infection.
  • To investigate the impact of HCV on liver disease progression, especially in HIV/HCV-coinfected individuals.

Main Methods:

  • Histopathological examination of liver biopsies and autopsy materials.
  • Immunohistochemistry for viral antigens (HCV, HBV), alpha-1-antitrypsin, and copper.
  • Immunostaining for ubiquitin to detect Mallory's hyalin and assess alcoholic liver disease.
  • Morphometric analysis of fibrosis and cirrhosis in HIV/HCV-coinfected patients versus HIV-negative controls.

Main Results:

  • Specific histological features aid in differentiating HCV from other liver diseases.
  • Immunohistochemistry is valuable for identifying viral co-infections and other causes of chronic liver disease.
  • HIV/HCV-coinfected patients exhibit significantly higher rates of fibrosis and cirrhosis compared to HIV-only patients.
  • Chronic HCV infection appears to worsen the progression of HIV infection, leading to liver failure.

Conclusions:

  • Liver biopsy remains a cornerstone for evaluating hepatitis C, guiding diagnosis, staging, and treatment assessment.
  • Morphological analysis, combined with immunohistochemistry, is critical for accurate diagnosis and understanding disease progression.
  • Hepatitis C significantly exacerbates liver disease in coinfected HIV patients, highlighting the need for vigilant management in this high-risk group.

Related Experiment Videos