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Negative interaction between lithium and electroconvulsive therapy--a case-control study

A K Jha1, G S Stein, P Fenwick

  • 1Department of Psychiatry, Farnborough Hospital, Kent.

The British Journal of Psychiatry : the Journal of Mental Science
|February 1, 1996
PubMed
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Concurrent lithium and electroconvulsive therapy (ECT) use does not increase adverse effects. This study found no significant differences in neurotoxicity or other adverse events between patients receiving combined treatment and those receiving ECT only.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Pharmacology

Background:

  • Concurrent lithium and electroconvulsive therapy (ECT) use is a clinical concern.
  • Potential for increased neurotoxicity with combined lithium/ECT treatment requires investigation.

Purpose of the Study:

  • To investigate the safety and adverse effects of combined lithium and ECT treatment.
  • To compare the incidence of adverse effects in patients receiving lithium/ECT versus ECT alone.

Main Methods:

  • Retrospective case-control study over an eight-year period.
  • Thirty-one subjects receiving combined lithium/ECT were compared to 135 ECT-only controls.
  • Cases were matched for age and sex.

Main Results:

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  • No significant differences in adverse effects between the lithium/ECT group and the ECT-only group.
  • Brief delirium occurred in 10% of the lithium/ECT group and 11% of controls.
  • No prolonged confusion was observed in the lithium/ECT group, while three controls developed it.

Conclusions:

  • Combined lithium and ECT treatment is not associated with a higher frequency of adverse effects.
  • The study suggests that concurrent lithium and ECT is a safe treatment option regarding neurotoxicity.