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Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures
H Saito1, T Fujiwara, E I Takahashi
1Department of Biochemistry, Cancer Institute, Tokyo, Japan.
Genomics
|February 1, 1996
Abstract:
We have isolated and characterized a cDNA clone, termed OTK18, representing a novel human gene. The 3754 nucleotides of this clone contain an open reading frame of 2133 nucleotides. As the predicted 711-amino-acid protein contains 13 contiguous zinc-finger stuctures of the C2H2 type, it would be expected to function as a DNA-binding multi-finger protein. The 4.3-kb transcript was expressed in all adult human tissues examined by Northern analysis. The gene was assigned to chromosomal band 19q13.4 by fluorescence in situ hybridization.