Related Experiment Videos
Molecular cloning of the N-terminus of GTBP
N C Nicolaides1, F Palombo, K W Kinzler
1Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
Genomics
|February 1, 1996
Abstract:
Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.