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Related Experiment Videos

Early urethral obstruction sequence: a lethal entity?

A F Bierkens1, W F Feitz, J G Nijhuis

  • 1Pediatric Urological Center, University Hospital, Nijmegen, Netherlands.

Fetal Diagnosis and Therapy
|March 1, 1996
PubMed
Summary
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Early urethral obstruction sequence (EUOS) in fetuses leads to severe complications. Prenatal intervention effectiveness is uncertain, suggesting pregnancy termination discussion for suspected EUOS cases.

Area of Science:

  • Perinatology
  • Fetal Medicine
  • Pediatric Urology

Background:

  • Early urethral obstruction sequence (EUOS) involves fetal bladder distension.
  • It can cause renal dysplasia, hydronephrosis, oligohydramnios, and lung hypoplasia.

Purpose of the Study:

  • To review the outcomes of fetuses diagnosed with suspected EUOS.
  • To evaluate the impact of EUOS on fetal development and survival.

Main Methods:

  • Retrospective review of 18 fetuses with suspected EUOS.
  • Analysis of gestational age at diagnosis, interventions, and autopsy findings.

Main Results:

  • Diagnosis occurred at a mean gestational age of 15 weeks.
  • 11 pregnancies were terminated; 9 showed pulmonary hypoplasia and renal disease.

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  • All 7 live births resulted in early death due to respiratory failure and lung hypoplasia.

    • Conclusions:

    • Prenatal intervention efficacy for preventing renal dysplasia and lung hypoplasia in EUOS is unclear.
    • Termination of pregnancy should be considered for suspected EUOS due to poor outcomes.