Role of IL12 as an anti-tumour agent: current status and future directions

Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis.

Journal of immunology (Baltimore, Md. : 1950)·2001

Peginterferon alfa-2a in patients with chronic hepatitis C.

The New England journal of medicine·2000

Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.

Journal of immunology (Baltimore, Md. : 1950)·1998

Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12.

Journal of the National Cancer Institute·1997

Interferon immunogenicity: preclinical evaluation of interferon-alpha 2a.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1997

Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis.

The American journal of pathology·1997

T-cell design: optimizing the therapeutic potential of autoreactive T cells by genetic modification.

Research in immunology·1999

Immune cell entry to the CNS--a focus for immunoregulation of EAE.

Research in immunology·1999

Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production.

Research in immunology·1998

Locally Aggressive Breast Desmoid Fibromatosis in a Young Woman With Multiple Fibroadenomas.

International journal of surgical pathology·2026

Tebentafusp desensitization in an adult with metastatic uveal melanoma.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026

Expression of V‑domain Ig suppressor of T cell activation in ovarian cancer and its regulation of follicular regulatory T‑cell function via the AKT/MAPK pathway.

Oncology reports·2026

Adjuvant immunotherapy versus observation after neoadjuvant therapy and esophagectomy for esophageal cancer with residual pathologic disease: a systematic review and reconstructed individual participant data meta-analysis.

Frontiers in immunology·2026

Small intestine intussusception causing intestinal obstruction secondary to left pinna melanoma metastases: a case report.

Frontiers in surgery·2026

A malignancy risk prediction model for Bethesda category III thyroid nodules based on serological indicators, C-TIRADS, and BRAF V600E testing.

Frontiers in endocrinology·2026

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Role of IL12 as an anti-tumour agent: current status and future directions

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Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis.

Peginterferon alfa-2a in patients with chronic hepatitis C.

Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.

Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12.

Interferon immunogenicity: preclinical evaluation of interferon-alpha 2a.

Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis.

T-cell design: optimizing the therapeutic potential of autoreactive T cells by genetic modification.

Immune cell entry to the CNS--a focus for immunoregulation of EAE.

Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production.

Locally Aggressive Breast Desmoid Fibromatosis in a Young Woman With Multiple Fibroadenomas.

Tebentafusp desensitization in an adult with metastatic uveal melanoma.

Expression of V‑domain Ig suppressor of T cell activation in ovarian cancer and its regulation of follicular regulatory T‑cell function via the AKT/MAPK pathway.

Adjuvant immunotherapy versus observation after neoadjuvant therapy and esophagectomy for esophageal cancer with residual pathologic disease: a systematic review and reconstructed individual participant data meta-analysis.

Small intestine intussusception causing intestinal obstruction secondary to left pinna melanoma metastases: a case report.

A malignancy risk prediction model for Bethesda category III thyroid nodules based on serological indicators, C-TIRADS, and BRAF V600E testing.

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Role of IL12 as an anti-tumour agent: current status and future directions

Related Concept Videos

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