Related Experiment Video
Updated: Aug 12, 2026
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
Published on: March 26, 2015
Animal models of demyelination
1Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
In the past year, animal studies on central nervous system demyelination have focused on therapeutic strategies and the functional characterization of T-cells, cytokines, and adhesion molecules. Significant progress has been realized in the treatment of animals with experimentally induced demyelinating disease using glial cell transplants, autoantibodies, cytokines, growth factors, and by inhibiting adhesion molecules and cytokines. In this review, we summarize the important contributions made in those respective areas.
In the past year, animal studies on central nervous system demyelination have focused on therapeutic strategies and the functional characterization of T-cells, cytokines, and adhesion molecules. Significant progress has been realized in the treatment of animals with experimentally induced demyelinating disease using glial cell transplants, autoantibodies, cytokines, growth factors, and by inhibiting adhesion molecules and cytokines. In this review, we summarize the important contributions made in those respective areas.
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