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Neurotransmitters and neuropeptides in headache
V Limmroth1, F M Cutrer, M A Moskowitz
1Department of Neurology, University of Essen, Germany.
Current Opinion in Neurology
|June 1, 1996
Summary
Migraine research is shifting from blood vessel dilation to neurogenic inflammation. New understanding of neuropeptides and receptors offers novel therapeutic targets for headache and migraine relief.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Traditional migraine theories focused on cranial blood vessel dilation.
- Early treatments like ergotamine and sumatriptan targeted vasoconstriction.
- Emerging research highlights the role of neuropeptides and neurogenic inflammation.
Purpose of the Study:
- To challenge the traditional vascular theory of migraine.
- To explore the emerging role of neuropeptides and neurogenic inflammation in migraine pathophysiology.
- To discuss neurotransmitters, neuropeptides, and their receptors as potential drug targets.
Main Methods:
- Utilizing animal models to study migraine mechanisms.
- Applying molecular pharmacology to investigate neuronal pathways.
- Analyzing neuropeptide release from primary afferent fibers.
Main Results:
- Evidence suggests neurogenic inflammation in the meninges is crucial.
- Neuropeptide release from primary afferent fibers contributes to migraine.
- Neurogenic inflammation models aid in defining drug targets.
Conclusions:
- The understanding of migraine is evolving beyond vascular mechanisms.
- Neuropeptides and neurogenic inflammation are key factors in migraine.
- Receptors for neurotransmitters and neuropeptides represent promising therapeutic targets for migraine treatment.