Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preterm labour and delivery

R S Black1, S Flint, C Lees

  • 1Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, Denmark Hill, London.

European Journal of Pediatrics
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Awaiting results of the TRUFFLE-2 randomized controlled trial: what are the expectations among investigators?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

ISUOG Consensus Statement on maternal hemodynamic assessment in hypertensive disorders of pregnancy and fetal growth restriction.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Interpretation of computerized cardiotocography criteria remains elusive.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

First-trimester ultrasound and research: should we keep driving without a license?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Perinatal outcomes after selective third-trimester ultrasound screening for small-for-gestational age: prospective cohort study nested within DESiGN randomized controlled trial.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Determining psychological impact of delivery mode prediction obtained from ultrasound and clinical assessment.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same journal

Long-term recurrence and acute seizure clustering in children with convulsions with mild gastroenteritis: a systematic review and meta-analysis.

European journal of pediatrics·2026
Same journal

Cost-benefit analysis of nirsevimab for respiratory syncytial virus prevention in infants: a population-based study.

European journal of pediatrics·2026
Same journal

Consensus statement on the use of standardized early mobilization in pediatric patients admitted to pediatric intensive care units in Italy.

European journal of pediatrics·2026
Same journal

Ultrasound-guided midline catheters in the neonatal intensive care unit: a single-center pilot study.

European journal of pediatrics·2026
Same journal

Gastrointestinal pathogens in paediatric patients with diarrhoea during the COVID-19 pandemic in Spain: a multicentre molecular-based prospective study.

European journal of pediatrics·2026
Same journal

Low serum immunoglobulin levels in pediatric atopic dermatitis: association with disease severity and exploratory scores.

European journal of pediatrics·2026
See all related articles

Glyceryl trinitrate (GTN), a nitric oxide (NO) donor, shows promise in preventing preterm birth by prolonging gestation. Early findings suggest GTN is a safe and effective tocolytic agent, with ongoing trials to confirm its impact on neonatal outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Pharmacology

Background:

  • Preterm birth is a leading cause of neonatal morbidity and mortality, with poorly understood pathogenesis.
  • Current methods for predicting preterm labor and existing tocolytic therapies have limited efficacy and significant side effects.
  • Nitric oxide (NO), a smooth muscle relaxant, is present in human myometrium, suggesting a potential therapeutic pathway.

Purpose of the Study:

  • To investigate the efficacy of glyceryl trinitrate (GTN), a nitric oxide (NO) donor, in prolonging gestation.
  • To evaluate GTN as a potential tocolytic agent for managing preterm labor.
  • To assess the safety and effectiveness of GTN compared to standard treatments.

Main Methods:

  • Observational study to assess the potential of glyceryl trinitrate (GTN) in prolonging gestation.

Related Experiment Videos

  • Ongoing randomized controlled trial comparing GTN with intravenous ritodrine for preterm labor management.
  • Monitoring of maternal and fetal side effects associated with GTN treatment.

    • Main Results:

    • Observational data suggest glyceryl trinitrate (GTN) may be effective in prolonging pregnancy.
    • Early clinical observations indicate few side effects associated with GTN use.
    • A randomized trial is underway to compare GTN with ritodrine, with results anticipated in Spring 1997.

    Conclusions:

    • Glyceryl trinitrate (GTN), as a nitric oxide (NO) donor, presents as a potentially safe and effective tocolytic agent.
    • Encouraging early findings suggest GTN could be a breakthrough in managing preterm labor.
    • Further results from ongoing randomized trials are crucial to establish the clinical significance of GTN in preventing preterm birth.