Related Experiment Videos
Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message
A Azuma1, H Miyachi, Y Shibata
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biological & Pharmaceutical Bulletin
|July 1, 1996
Abstract:
N(alpha)-Phthalimidoglutarimide (thalidomide), 2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (PP-33) and its 4,5,6,7-tetrafluoro derivative (FPP-33) augmented 12-O-tetradecanoylphorbol 13-acetate-induced production by human leukemia HL-60 cells of both tumor necrosis factor alpha (TNF-alpha) mRNA and secreted TNF-alpha protein. Intracellular TNF-alpha protein production was increased to a lesser extent.