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Localization of GABAA alpha 1 mRNA subunit in the brainstem nuclei controlling esophageal peristalsis
D L Broussard1, X Li, S M Altschuler
1Division of Gastrenterology and Nutrition, Children's Hospital of Philadelphia, PA 19104, USA.
Brain Research. Molecular Brain Research
|August 1, 1996
Abstract:
The nucleus of the solitary tract, the site of esophageal premotor neurons (PMN), is tonically inhibited by GABAergic neurons via the GABAA receptor. We investigated the expression of GABAA alpha 1 subunit mRNA within esophageal PMNs of the NTS utilizing transynaptic tracing with pseudorabies virus and nonisotopic in-situ hybridization. Double-labeling studies revealed that the majority of PRV-immunoreactive cells also expressed GABAA alpha 1 mRNA. The expression of GABAA subunits supports a role for GABA in the brainstem circuit controlling esophageal peristalsis.