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Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS
A Makoff1, C Pilling, K Harrington
1Biology Division, Wellcome Foundation, Kent, UK.
Brain Research. Molecular Brain Research
|August 1, 1996
Abstract:
Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.