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Prolonged ciprofloxacin administration does not accelerate neutrophil recovery after autologous bone marrow
1University of Toronto Autologous Blood and Marrow Transplant Program, Toronto Hospital, Ontario, Canada.
Study Objective:
To determine whether prolonged ciprofloxacin administration following autologous bone marrow transplantation (ABMT) accelerates neutrophil recovery.
Design:
Retrospective analysis of 40 consecutive patients undergoing ABMT.
Setting:
Tertiary care bone marrow transplant program.
Patients:
Two sequential arms of 20 consecutive patients with Hodgkin's disease or non-Hodgkin's lymphoma undergoing ABMT.
Interventions:
The first arm received ciprofloxacin from the day of transplantation until initiation of broad-spectrum antibiotic therapy (median 5 days) while the second arm continued ciprofloxacin until recovery of the neutrophil count (median 15 days).
Measurements And Main Results:
Neutrophil recovery was similar in the two groups (16 vs 14 days; p = 0.41). There were no differences in platelet recovery, bacteremia, or treatment-related mortality.
Conclusion:
Prolonged ciprofloxacin administration does not significantly accelerate neutrophil recovery following ABMT.