Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53, apoptosis and human cancers

T H Wang1, H S Wang

  • 1Department of Obstetrics and Gynecology, University of Tennessee Medical Center at Knoxville, USA.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[STING-associated vasculopathy with onset in infancy: a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
Same author

[Clinicopathological characteristics and prognostic factors in 36 cases of early-stage gastric mixed adenoneuroendocrine carcinoma].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same author

Extracellular Z-DNA Enhances Cariogenicity of Biofilm.

Journal of dental research·2025
Same author

[Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma].

Zhonghua yi xue za zhi·2024
Same author

[Analysis of efficacy and prognosis of allogeneic hematopoietic stem cell transplantation for the treatment of combined immunodeficiency].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same author

[A case of neonatal multi-system Langerhans cell histiocytosis treated by dabrafenib].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2023

Mutations in the p53 tumor suppressor gene are common in human cancers, often inhibiting apoptosis and promoting tumor growth. Targeting apoptosis pathways offers promising anticancer therapy strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Over 50% of human cancers exhibit mutations in the p53 gene.
  • p53 mutations frequently occur at DNA contact sites or regions critical for protein conformation.
  • Loss of wild-type p53 function leads to apoptosis inhibition, potentially via impaired bax gene activation.

Purpose of the Study:

  • To investigate the role of p53 mutations and apoptosis inhibition in human cancer development.
  • To explore the link between p53 mutations, apoptosis, and tumorigenesis.
  • To identify therapeutic strategies based on p53 function and apoptosis.

Main Methods:

  • Structural analysis of p53-DNA interactions.
  • Correlation studies of UV-induced p53 mutations, apoptosis inhibition, and skin cancer.

Related Experiment Videos

  • Investigation of hypoxia-mediated selection in solid tumors.
  • Gene therapy approaches to restore wild-type p53 function.

    • Main Results:

    • p53 mutation 'hot spots' are often involved in direct DNA binding or maintaining p53 conformation.
    • UV-induced p53 mutations in keratocytes correlate with apoptosis inhibition and skin cancer.
    • Hypoxia may select for p53 mutant cells with reduced apoptosis, explaining high mutation prevalence.
    • Gene therapy restoring wild-type p53 shows encouraging results.

    Conclusions:

    • Inhibited apoptosis is a key mechanism linking p53 mutations to tumorigenesis.
    • Understanding p53's role in apoptosis informs novel anticancer therapies.
    • Developing p53-independent apoptosis induction strategies is crucial for effective cancer treatment.